"Within three weeks, the tumors had been blown away, in a way that was much more violent than we ever expected," said senior author Carl June, MD, director of Translational Research and a professor of Pathology and Laboratory Medicine in the Abramson Cancer Center, who led the work. "It worked much better than we thought it would."Patient's tumors disappeared and they went into remission, up to a year so far.
"We saw at least a 1000-fold increase in the number of modified T cells in each of the patients. Drugs don't do that," June says. "In addition to an extensive capacity for self-replication, the infused T cells are serial killers. On average, each infused T cell led to the killing of thousands of tumor cells – and overall, destroyed at least two pounds of tumor in each patient."The research team have plans to try the same gene manipulaton on other lymphomas, and leukemias. Read the full article here
Time and more trials, and patients, will tell a fuller story, but at this point, it sounds promising for CLL patients right now, and possibly for many others in the coming years.